The Problem
Synovitis The painful facts
There is strong evidence that synovitis is associated with further worsening of OA structure.
The Problem
There is strong evidence that synovitis is associated with further worsening of OA structure.
UK
The synovium is a specialised connective tissue that lines the inside of the joint capsule. In the knee, the synovium seals the synovial cavity, maintains the synovial fluid and helps with chondrocyte nutrition and subchondral bone.
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Inflammation of the synovial membrane known as synovial pain (synovitis) is common in OA joints and has been associated both with symptoms and structural degradation.
Fact 1
Presenting early in the disease course, synovitis is also strongly associated with pain severity in patients with knee OA.
Fact 2
The characteristics of the synovium in OA knee patients are synovial lining hyperplasia, sublining fibrosis and stromal vascularization.
Fact 3
In an inflamed state, the predominant immune cells found in the synovium of a knee OA patient are macrophages and T-Cells. This is due to an influx of white blood cells/ leukocytes responding to cytokines and cell adhesion molecules.
Fact 4
In addition to its relationship with knee pain, synovitis is also strongly associated with more rapid progression of cartilage loss in OA joints and the initiation of cartilage loss in joints without OA.
Targeting synovial inflammation in early OA could therefore prove a promising therapeutic approach for alleviating the symptoms suffered by patients, slowing down disease progression, and potentially even preventing articular cartilage destruction.
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