Introducing Arthrosamid®

Redefining treatment for knee OA, without surgery

Arthrosamid® is a non-biodegradable 2.5 iPAAG injectable implant that delivers long-lasting pain relief — improving the quality of life for patients with knee OA.

What is Arthrosamid®?

Arthrosamid® is a single, minimally invasive, long-lasting knee OA treatment — a non-biodegradable injectable polyacrylamide hydrogel (2.5 iPAAG) for intra-articular use.

Relieve pain and improve the function of the knee affected by knee OA, with a simple, one-step outpatient procedure.

Pioneering

Arthrosamid® is a first-in-class synovial scaffold delivered as a single, minimally invasive out-patient procedure performed under local anaesthesia, with ultrasound guidance.

Proven

Arthrosamid® is safe for intended use and has undergone more than 20 years of research and development.

Pain Relief Treatment

A single, minimally invasive, long-lasting knee OA treatment, Arthrosamid® has demonstrated an improvement in quality of life with patients in clinical trials reporting a reduction in pain by Week 4 — and lasting over 4 years.

What is 2.5 iPAAG?

Intra-articular injectable polyacrylamide hydrogel (2.5 iPAAG) in Arthrosamid® is made up of 2.5% cross-linked polyacrylamide and 97.5% water.

Biocompatible: permeable to salts and organic molecules the hydrogel is able to integrate with soft tissue
Viscoelastic: cross-linked chains of polymer allow flexible shea
Non-degradable: structural stability of hydrogel provides longevity of action

iPAAG: injectable polyacrylamide hydrogel

Undergone

over 20 years

of research and development

Around

1,200,000 syringes of 2.5 iPAAG

have been made for human use

Arthrosamid® remains

safe and effective

for its intended use 4 years after treatment

Biocompatible

permeable to salts and organic molecules the hydrogel is able to integrate with soft tissue

Viscoelastic

cross-linked chains of polymer allow flexible shear

Non-degradable

structural stability of hydrogel provides longevity of action

Arthrosamid® is the first and only approved 2.5 iPAAG treatment that permanently integrates into the synovial membrane — decreasing joint stiffness, diminishing pain, and improving the function of the knee.

Acting as a synovial scaffold, Arthrosamid® distributes within the synovial fluid to fully integrate into the synovial membrane, thickening it and providing a physical barrier that breaks the inflammatory cycle to relieve pain.

Mode of Action — let’s take a closer look

Untreated OA knee: the synovial fluid loses its viscoelastic properties. The synovial membrane contains an accumulation of inflammatory cells that are a precursor to pain and swelling.

Arthrosamid is injected into the joint cavity, distributes within the joint fluid, and begins to adhere to the synovial lining.

Macrophage-like synoviocytes (MLS) enter the hydrogel but are unable to phagocytise it.

The MLS cells differentiate into fibroblast-like synoviocytes (FLS) which start integrating through the hydrogel, creating a thin vessel-bearing fibrous network.

A new layer of intima forms on the top of the integrated iPAAG synovial membrane. This new layer consists of scattered non-inflammatory type cells, with the iPAAG acting as a scaffold within the sub-intima layer. This process takes 1 month.

The thickening of the synovial sub-intima layer causes distancing of the inflammatory cells and breaks the inflammatory cycle.

Untreated OA knee: the synovial fluid loses its viscoelastic properties. The synovial membrane contains an accumulation of inflammatory cells that are a precursor to pain and swelling.

How to inject Arthrosamid®

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Oral antibiotics must be taken 1-2 hours before injection to reduce risk of infection. If available, use Ultrasound to ensure correct placement of needle into knee joint space.

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2. Conduct the procedure using aseptic conditions and a no-touch technique. Swab at least 5cm around the injection site and use a local anaesthetic to numb the skin around it. Prepare 6 x 1ml Arthrosamid® syringes by removing from blister packs and laying on table for easy access.