Introducing Arthrosamid®
Redefining treatment for knee OA, without surgery
Arthrosamid® is a non-biodegradable 2.5 iPAAG injectable implant that delivers long-lasting pain relief — improving the quality of life for patients with knee OA.
What is Arthrosamid®?
Arthrosamid® is a single, minimally invasive, long-lasting knee OA treatment — a non-biodegradable injectable polyacrylamide hydrogel (2.5 iPAAG) for intra-articular use.
Relieve pain and improve the function of the knee affected by knee OA, with a simple, one-step outpatient procedure.
Pioneering
Arthrosamid® is a first-in-class synovial scaffolddelivered as a single, minimally invasive out-patient procedure performed under local anaesthesia, with ultrasound guidance.
Proven
Arthrosamid® is safe for intended use and has undergone more than 20 years of research and development.
Pain Relief Treatment
A single, minimally invasive, long-lasting knee OA treatment, Arthrosamid® has demonstrated an improvement in quality of life with patients in clinical trials reporting a reduction in pain by Week 4 — and lasting over 3 years.
What is 2.5 iPAAG?
Intra-articular injectable polyacrylamide hydrogel (2.5 iPAAG) in Arthrosamid® is made up of 2.5% cross-linked polyacrylamide and 97.5% water.
- Biocompatible: permeable to salts and organic molecules the hydrogel is able to integrate with soft tissue
- Viscoelastic: cross-linked chains of polymer allow flexible shea
Non-degradable: structural stability of hydrogel provides longevity of action
iPAAG: injectable polyacrylamide hydrogel
Undergone
over 20 years
of research and development
Around
1,200,000 syringes of 2.5 iPAAG
have been made for human use.
Arthrosamid® remains
safe and effective
for its intended use 3 years after treatment.
Biocompatible
permeable to salts and organic molecules the hydrogel is able to integrate with soft tissue
Viscoelastic
cross-linked chains of polymer allow flexible shear
Non-degradable
structural stability of hydrogel provides longevity of action
Arthrosamid® is the first and only approved 2.5 iPAAG treatment that permanently integrates into the synovial membrane — decreasing joint stiffness, diminishing pain, and improving the function of the knee.
Acting as a synovial scaffold , Arthrosamid® distributes within the synovial fluid to fully integrate into the synovial membrane , thickening it and providing a physical barrier that breaks the inflammatory cycle to relieve pain.
Mode of Action — let’s take a closer look
Untreated OA knee: the synovial fluid loses its viscoelastic properties. The synovial membrane contains an accumulation of inflammatory cells that are a precursor to pain and swelling.
Arthrosamid is injected into the joint cavity, distributes within the joint fluid, and begins to adhere to the synovial lining.
Macrophage-like synoviocytes (MLS) enter the hydrogel but are unable to phagocytise it.
The MLS cells differentiate into fibroblast-like synoviocytes (FLS) which start integrating through the hydrogel, creating a thin vessel-bearing fibrous network.
A new layer of intima forms on the top of the integrated iPAAG synovial membrane. This new layer consists of scattered non-inflammatory type cells, with the iPAAG acting as a scaffold within the sub-intima layer. This process takes 1 month.
The thickening of the synovial sub-intima layer causes distancing of the inflammatory cells and breaks the inflammatory cycle.
Untreated OA knee: the synovial fluid loses its viscoelastic properties. The synovial membrane contains an accumulation of inflammatory cells that are a precursor to pain and swelling.
How to inject Arthrosamid®
Ready to take the next step?
Pioneering, proven pain treatment for knee OA. Contact us to use Arthrosamid® iPAAG in your knee osteoarthritis patients today.