The Problem
Synovitis The painful facts
There is strong evidence that synovitis is associated with further worsening of OA structure.
What is the synovium?
The synovium is a specialised connective tissue that lines the inside of the joint capsule. In the knee, the synovium seals the synovial cavity, maintains the synovial fluid and helps with chondrocyte nutrition and subchondral bone.
There is strong evidence that synovitis is associated with further worsening of OA structure.
Synovitis—the painful facts
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Inflammation of the synovial membrane known as synovial pain (synovitis) is common in OA joints and has been associated both with symptoms and structural degradation.
Fact 1
Presenting early in the disease course, synovitis is also strongly associated with pain severity in patients with knee OA.
Fact 2
The characteristics of the synovium in OA knee patients are synovial lining hyperplasia, sublining fibrosis and stromal vascularization.
Fact 3
In an inflamed state, the predominant immune cells found in the synovium of a knee OA patient are macrophages and T-Cells. This is due to an influx of white blood cells/ leukocytes responding to cytokines and cell adhesion molecules.
Fact 4
Treating OA synovitis represents an important target for therapeutic intervention.
The link between synovitis and knee OA
Synovitis is known to play an important role in OA development.
In addition to its relationship with knee pain, synovitis is also strongly associated with more rapid progression of cartilage loss in OA joints and the initiation of cartilage loss in joints without OA.
Treating OA synovitis represents an important target for therapeutic intervention.
Targeting synovial inflammation in early OA could therefore prove a promising therapeutic approach for alleviating the symptoms suffered by patients, slowing down disease progression, and potentially even preventing articular cartilage destruction.
What is the place for Arthrosamid® in managing knee OA?
Redefining treatment for knee OA, without surgery. Learn how Arthrosamid® can help patients with knee osteoarthritis.