
The Problem
Osteoarthritis in the knee
Is the most common form of arthritis, and its incidence is rising. Without a cure, the most effective treatment remains total knee arthroplasty.

The Problem
Is the most common form of arthritis, and its incidence is rising. Without a cure, the most effective treatment remains total knee arthroplasty.
Whilst the exact cause and subsequent development of knee OA pain is unclear, clinical imaging and biochemical observations indicate that inflammation may contribute to both pain and structural disease progression.

Knee osteoarthritis (OA) is a long-term condition where the shock-absorbing cartilage is worn away causing bones to rub together and the joint to become stiff, swollen and painful. The knee joint worsens over time resulting in synovial pain and disability.
Despite OA being the most common type of arthritis and the fastest-growing cause of disability worldwide, the treatment area has seen minimal progression in the last 20 years. With so little known about exactly what causes knee OA, a permanent cure has yet to be discovered.

Have focused on pain relief and managing the symptoms of the condition
With surgical intervention through joint replacement, the only option for end-stage disease, there is a real need for better treatment strategies.
would pay for non-surgical procedures for chronic joint pain
are concerned about side effects of surgery e.g pain and discomfort
are anxious about surgery.